NTRK gene fusions have been found in more than 25 different cancer types, including, sarcoma, non-small cell lung cancer (NSCLC), salivary cancer, secretory breast cancer, and papillary thyroid cancer.
If you or a loved one has cancer, talk to your doctor about testing for the NTRK gene fusion.
For more information about NTRK gene fusions and TRK fusion proteins, go here.
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ROZLYTREK is a prescription medicine used to treat:
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The approval of ROZLYTREK was based on a study that measured response to treatment and duration of response. Continued approval for this use may depend on the results of an ongoing study to confirm the benefit of ROZLYTREK for this use.
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ROZLYTREK may cause serious side effects, including:
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Central nervous system, which includes the brain and spinal cord.
Cancer that develops in the colon, which is the longest part of the large intestine and/or the rectum (the last several inches of the large intestine before the anus).
The disappearance of all signs of cancer, such as tumors, in response to treatment. This does not mean the cancer has been cured.
Molecules within cells that carry genetic information.
A type of gene made by joining parts of 2 different genes. Fusion genes make fusion proteins, which can be the root cause of some kinds of cancer.
long QT syndrome
A condition where the heart beats fast and irregularly. Long QT syndrome might cause a person to faint or have a seizure. In some instances, the heart can beat out of control for so long that it may cause sudden death.
papillary thyroid cancer
The most common type of thyroid cancer.
The decrease in the size and spread of tumors or extent of cancer in the body in response to a given treatment.
A molecule that is needed for your body to function properly. Proteins are the basis of body structures, like skin and hair, and other substances in your body.
A rare cancer found in the tissues of the gland that makes saliva.
A cancer that begins in the bone and soft tissue.
secretory breast cancer
A rare type of breast cancer.
Cancer of the thyroid. The thyroid is an organ at the base of the throat. It makes hormones that help control heart rate, blood pressure, body temperature, and weight.
An NTRK gene fusion tells the body to make abnormal versions of TRK, or tropomyosin receptor kinase, fusion proteins. TRK fusion proteins are a family of several proteins that normally plays an important role in the nervous system. People with NTRK fusion-positive solid tumors have an abnormal version of TRK called a TRK fusion protein.
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