There are 3 different NTRK gene fusions:
TRK fusion proteins send signals that can cause cancer cells to develop, grow, and spread.
TRK=tropomyosin receptor kinase.
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Central nervous system, which includes the brain and spinal cord.
Cancer that develops in the colon, which is the longest part of the large intestine and/or the rectum (the last several inches of the large intestine before the anus).
The disappearance of all signs of cancer, such as tumors, in response to treatment. This does not mean the cancer has been cured.
Molecules within cells that carry genetic information.
A type of gene made by joining parts of 2 different genes. Fusion genes make fusion proteins, which can be the root cause of some kinds of cancer.
long QT syndrome
A condition where the heart beats fast and irregularly. Long QT syndrome might cause a person to faint or have a seizure. In some instances, the heart can beat out of control for so long that it may cause sudden death.
papillary thyroid cancer
The most common type of thyroid cancer.
The decrease in the size and spread of tumors or extent of cancer in the body in response to a given treatment.
A molecule that is needed for your body to function properly. Proteins are the basis of body structures, like skin and hair, and other substances in your body.
A rare cancer found in the tissues of the gland that makes saliva.
A cancer that begins in the bone and soft tissue.
secretory breast cancer
A rare type of breast cancer.
Cancer of the thyroid. The thyroid is an organ at the base of the throat. It makes hormones that help control heart rate, blood pressure, body temperature, and weight.
An NTRK gene fusion tells the body to make abnormal versions of TRK, or tropomyosin receptor kinase, fusion proteins. TRK fusion proteins are a family of several proteins that normally plays an important role in the nervous system. People with NTRK fusion-positive solid tumors have an abnormal version of TRK called a TRK fusion protein.
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